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thiL [2017-8-11 16:0:3]
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thiL [2017-8-11 16:0:3]

thiamine-monophosphate kinase
locus
BSU05900
pI
5.04
mw
35.73 kDa
protein length
325 aa Sequence Blast
gene length
975 bp Sequence Blast
function
biosynthesis of thiamine
product
thiamine-monophosphate kinase
essential
no
ec
2.7.4.16
synonyms
ydiA, ydxA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine]

    • Gene

    Coordinates
    640,662 → 641,639

    The protein

    Catalyzed reaction/ biological activity

  • ATP + thiamine phosphate = ADP + thiamine diphosphate (according to Swiss-Prot)

    • Protein family

  • thiamine-monophosphate kinase family (according to Swiss-Prot)

    • Structure

  • [PDB|1VQV] (from ''Aquifex aeolicus'', 33% similarity, 51% identity)

    • Expression and Regulation

    Operons

    genes
    [gene|DE32F1DA1EA1164411E0605262381BD38A49656C|thiL]-[gene|E15BB518649B2B9CD44CEBBB4FA481E55BCE823C|tsaE]-[gene|6CB350C335603D5F4434679F9D740BFECA738599|tsaB]-[gene|C2283BDD806221A285A27F24F52F92F4D47F0C55|ydiD]-[gene|30393F16CFE89E7BAD233A0BD27B77D679F7E409|tsaD]
    description
    [Pubmed|22383849]
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    Biological materials

    Mutant

  • MGNA-C197 (ydiA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2195 NBRP B. subtilis, Japan]

    • References

    Reviews

  • 19348578

    • Original publications

  • 16291685,22383849